This movie starts with Saze X playing basketball. Suddenly, a lightning bolt hit the earth. They walked towards it and found a boy. The boy's name is Ricky, and he thinks he has forgotten everything. On the other hand, Remy told Sazer-X that a giant monster named Mechanical Giant Bulgario had approached Earth and was destroying buildings. Sazer X still defeated the monster. But then something flashed into their eyes, and Takuto mistook it for a cosmic capsule. In fact, this is the Bosquito people that exist within Bulgaria, which Professor Horiguchi later explained.
这个被称为“疫苗世界”的地方在维度上与地球不同，是一个和平稳定的世界，四季如春。有一天，被封在那里的病毒之王“黑暗恶魔”逃跑了，朝着地球的方向逃跑。被这件事困扰的疫苗行业女神玛雅命令学徒守护兽麦丸追捕黑暗恶魔和他们所生的病毒。
